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A collection of Sexual Health Resources in Philadelphia

Below are links that can connect you to resources for sexual health

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Talk PrEP

TalkPrEP is an educational site about PrEP, the medication used to help prevent HIV transmission through sex. It's built to encourage people to "start a PrEP talk" — likely with a doctor — and covers a few main points: PrEP is about 99% effective when taken as prescribed, condoms add further protection against HIV and other STIs (which PrEP alone doesn't prevent), who should consider discussing PrEP (including groups most affected by HIV), and the impact PrEP has had by state. 

Philadelphia FIGHT

Philadelphia FIGHT is a community health organization in Philadelphia offering primary medical care, dental, behavioral health, pediatrics, and specialized services (including HIV care) across several health centers — the Jonathan Lax Center, John Bell Health Center, Y-HEP Health Center, and the newly opened Sam Morales Community Health Center. The site lets visitors book appointments, find a doctor, and locate health centers, and features news like a 2026 HIV Education Summit, new staff announcements, and their "FIGHT Stories" project sharing client stories.

Mazzoni Center

Mazzoni Center is Philadelphia's primary LGBTQ+ health and wellness center, serving the community since 1979 with a "whole-person care" approach. The site highlights three core services: medical/primary care, sexual health (HIV/STI testing, PrEP navigation), and behavioral health (therapy, psychiatry, integrated counseling). It also offers a patient portal for secure communication, plus a calendar of community programs — support groups for topics like HIV+ aging, LGBTQ+ youth health advocacy, and queer relationship-building.

Action Wellness

Action Wellness is a nonprofit that supports people living with HIV and those at high risk of acquiring it, offering trauma-informed social services aimed at physical, emotional, and economic well-being. The organization runs on about 80 professional staff and 200 volunteers, serving over 2,000 clients and their families each year. The site highlights ways to get involved — donating, volunteering, or applying for open jobs — along with client testimonials about services like housing help, therapy referrals, and support groups.

Image by Marek Studzinski

PrEP is ~99% effective at preventing HIV through sex

Resources

1.
Centers for Disease Control and Prevention. US Public Health Service: Preexposure prophylaxis for the prevention of HIV infection in the United States—2021 update: a clinical practice guideline. Published December 2021. Accessed October 27, 2025. https://stacks.cdc.gov/view/cdc/112360

2.
Centers for Disease Control and Prevention. HIV Nexus: CDC resources for clinicians. Updated August 20, 2024. Accessed September 4, 2024. https://www.cdc.gov/hivnexus/hcp/prep/index.html

3.
Smith DK, Herbst JH, Zhang X, Rose CE. Condom effectiveness for HIV prevention by consistency of use among men who have sex with men in the United States. J Acquir Immune Defic Syndr. 2015;68(3):337-344.

4.
US Preventive Services Task Force; Owens DK, Davidson KW, Krist AH, et al. Preexposure prophylaxis for the prevention of HIV infection: US Preventive Services Task Force recommendation statement. JAMA. 2019;321(22):2203-2213.

5.
Sullivan PS, Dubose S, Brisco K, Gordon L, Juhasz M. Association of state-level PrEP coverage and state-level HIV diagnosis, US, 2012-2021. Abstract presented at: Conference on Retroviruses and Opportunistic Infections (CROI); March 3-6, 2024; Denver, CO.

6.
Tao L, Yang J, Zachry W, Gruber J, Mezzio D. The real-world impact of pre-exposure prophylaxis (PrEP) prescription uptake and dispensing status on HIV infection risk in the US. Poster presented at: IDWeek 2023; October 11-15, 2023; Boston, MA. Poster 1557.

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